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On the cover: Images of o2 and wild-type kernels in different genetic back-grounds illustrate the impact of genetic background on the mutant phenotype. The overlay is a plot of the degree of differential expression (o2 vs. wild-type) of genes in a genetic background with a severe o2 phenotype vs. the degree of differential expression of the same genes in a genetic background with a mild o2 phenotype. Photo by Joan Peterson.