Crop Science Journal of Natural Resources and Life Sciences Education
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Published online 18 December 2007
Published in Crop Sci 47:S-60-S-71 (2007)
© 2007 Crop Science Society of America
677 S. Segoe Rd., Madison, WI 53711 USA
This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Veyrieras, J.-B.
Right arrow Articles by Charcosset, A.
PubMed
Right arrow Articles by Veyrieras, J.-B.
Right arrow Articles by Charcosset, A.
Agricola
Right arrow Articles by Veyrieras, J.-B.
Right arrow Articles by Charcosset, A.
Related Collections
Right arrow Crop Genetics
Right arrow Maize

Bridging Genomics and Genetic Diversity: Linkage Disequilibrium Structure and Association Mapping in Maize and Other Cereals

Jean-Baptiste Veyrierasa, Letizia Camus-Kulandaivelua, Brigitte Gouesnardb, Domenica Manicaccia and Alain Charcosseta,*

a UMR 8120 Génétique Végétale, INRA UPS INA-PG CNRS, Ferme du Moulon, 91190 Gif sur Yvette, France
b UMR 1097 Diversité et Génomes des Plantes Cultivées, INRA Domaine de Melgueil, 34130 Mauguio, France

* Corresponding author (charcos{at}moulon.inra.fr).

Linkage disequilibrium (LD) and association mapping is receiving considerable attention in the plant genetics community for its potential to use existing genetic resources collections to fine map quantitative trait loci (QTL), validate candidate genes, and identify alleles of interest. Based on investigations in maize (Zea mays L.) either published or recently conducted in our group, we discuss three elements of particular importance for conducting association mapping or interpreting the results: (i) the analysis of population structure into subgroups, (ii) its use to control for spurious associations and consequences in the specific case of differential selection among subgroups, and (iii) the analysis of the local structure of LD into haplotypes and its consequences on the resolution and the application of LD mapping. Consequences and perspectives for plant breeding are briefly discussed.

Abbreviations: HMM, Hidden Markov Model • LD, linkage disequilibrium • PCA, principal component analysis • QTL, quantitative trait loci • SSR, simple sequence repeat

Received for publication April 7, 2007.




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
The SCI Journals Agronomy Journal Vadose Zone Journal
Journal of Plant Registrations Soil Science Society of America Journal
Journal of Natural Resources
and Life Sciences Education		 Journal of
Environmental Quality
Copyright © 2007 by the Crop Science Society of America.